Your Drug May Be Your Problem: How & Why to Stop Taking Psychiatric Medications (Revised Edition)

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Taking Trintellix with drugs that reduce blood clotting might increase the risk of stomach bleeding. In some cases, this could be serious. This can increase the risk of serious side effects from the drug, including serotonin syndrome. If you take these medications, your doctor may prescribe a lower dosage of Trintellix.

Examples of these medications include:. Certain medications that make an enzyme called cytochrome P 3A4 CYP3A4 more active can increase how fast the body breaks down Trintellix. This can make Trintellix less effective. If you take these medications, your doctor may prescribe a higher dosage of Trintellix.

Your Drug May Be Your Problem - Chapter 1

Trintellix and Vyvanse lisdexamfetamine are sometimes prescribed together, especially for people who have both attention deficit hyperactivity disorder ADHD and depression. These medications should only be taken together if your doctor prescribes them. Combining Trintellix and Vyvanse can increase your risk of developing serotonin syndrome, a drug reaction that can be dangerous.

Trintellix can interact with certain supplements or herbs you may be taking. Supplements that affect serotonin levels can increase your risk of developing serotonin syndrome. Trintellix can be taken with or without food. Taking it with food might help decrease stomach upset caused by the medication.

The manufacturer hasn't stated whether it's safe to crush Trintellix tablets. Therefore, it might be safer to avoid crushing them. Trintellix can be taken either in the morning or at night. Some people who take Trintellix can feel restless, energized, or have trouble sleeping soon after they take the medication. If this happens to you, try taking Trintellix in the morning. Trintellix is a unique antidepressant medication because of the way it works.

It's sometimes called an atypical antidepressant or a multimodal antidepressant. Like many antidepressants, Trintellix increases serotonin activity by blocking the reabsorption reuptake of serotonin in the brain. This increase in serotonin might help balance out levels of brain chemicals to help improve symptoms of depression. But unlike other antidepressants, Trintellix also binds to and blocks certain types of serotonin receptors in the brain.

Receptors are like docking stations on cells, and serotonin attaches to them. But when Trintellix blocks these receptors, serotonin can't attach to them. It's not clear how this action helps relieve depression. Most antidepressants, including Trintellix, don't work quickly. Although you may feel some effects sooner, the maximum effect on depression symptoms usually doesn't happen for six to eight weeks after you start taking the medication.

There are many different antidepressant medications that are effective for treating major depressive disorder, the condition that Trintellix is approved to treat. If the first antidepressant tried doesn't help or only partially helps, the next step is often trying an antidepressant from a different drug class. A drug class is a group of medications that work in a similar way.

Options from other antidepressant drug classes can be alternatives to Trintellix. The different drug classes of antidepressants include:. You may wonder how certain drugs compare to Trintellix. Below are comparisons between Trintellix and several other medications. Trintellix and Viibryd vilazodone are both brand-name prescription antidepressant medications.

They each affect serotonin, a chemical messenger in the brain, but they work slightly differently. In an indirect comparison of antidepressants , users were less likely to stop taking Trintellix because of side effects than they were Viibryd. The effectiveness of Trintellix and Viibryd in treating MDD hasn't been directly compared in clinical studies. However, an indirect comparison of antidepressants showed that Trintellix and Viibryd work about equally well. Trintellix and Viibryd are both available only as brand-name drugs. They don't have generic forms, which are typically less expensive than brand-name versions.

Trintellix usually costs more than Viibryd.

FDA warning: Risk of suicidal thoughts in children

The actual amount you pay will depend on your insurance plan. Trintellix and Effexor XR venlafaxine are both prescription antidepressant medications. They both affect serotonin, a chemical messenger in the brain, but Effexor XR also affects norepinephrine. Effexor XR is also approved for other uses, including:. Effexor XR comes as an extended-release capsule that's taken once daily.

A generic immediate-release tablet is also available that's taken two to three times daily. Trintellix and Effexor XR and generic Effexor have some similar side effects, and some that differ.

Below are examples of these side effects. In an indirect comparison of antidepressants , users were less likely to stop taking Trintellix because of side effects than Effexor. The effectiveness of these drugs in treating MDD hasn't been directly compared in clinical studies. However, an indirect comparison of antidepressants showed that Effexor may be slightly more effective than Trintellix.

Trintellix is only available as a brand-name drug. Effexor XR capsules are available as a brand-name drug and in a generic form called venlafaxine. Effexor oral tablets are only available in generic form. Effexor XR is similar in price to Trintellix. Generic Effexor XR is typically less expensive than both brand-name products. In any case, the actual amount you pay will depend on your insurance plan. Trintellix and Wellbutrin bupropion are both prescription antidepressant medications. Trintellix mainly affects serotonin, a chemical messenger in the brain. Wellbutrin affects different chemical messengers called norepinephrine and dopamine.

Trintellix comes only as an oral tablet that's taken once daily. Wellbutrin XL and Wellbutrin SR both come as extended-release tablets that are taken once daily in the morning. However, an indirect comparison of antidepressants showed that Trintellix may be more effective than Wellbutrin.

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Their generic names are bupropion XL and bupropion SR. Trintellix and Celexa citalopram are both prescription antidepressant medications.


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They both affect serotonin, a chemical messenger in the brain, but they work slightly differently. Trintellix and Celexa have some similar side effects, and some that differ. The effectiveness of Trintellix and Celexa in treating MDD hasn't been directly compared in clinical studies.

However, an indirect comparison of antidepressants showed that Trintellix may be slightly more effective than Celexa. Trintellix comes only as a brand-name drug. Celexa comes as a brand-name drug and in a generic form called citalopram. The generic form of Celexa is much less expensive than Trintellix. Also, brand-name Celexa is usually less expensive than Trintellix. Trintellix and Lexapro escitalopram are both prescription antidepressant medications. Lexapro is also approved for treating generalized anxiety disorder.

Trintellix and Lexapro have some similar side effects, and some that differ. The effectiveness of Trintellix and Lexapro in treating MDD hasn't been directly compared in clinical studies. However, an indirect comparison of antidepressants showed that Trintellix and Lexapro work about equally well.

Lexapro is available as a brand-name drug and in a generic form called escitalopram. Generic Lexapro is much less expensive than Trintellix. Brand-name Lexapro is also usually slightly less expensive than Trintellix. Trintellix and Prozac fluoxetine are both prescription antidepressant medications.

Prozac is also approved for treating other conditions, including:. Trintellix comes as an oral tablet that's taken once daily. Prozac comes as an oral pulvule, which is a type of capsule. It's usually taken once daily in the morning.

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Your Drug May Be Your Problem: How and Why to Stop Taking Psychiatric Medications

Prozac also comes as a delayed-release capsule that's taken once weekly. Trintellix and Prozac have some similar side effects, and some that differ. However, an indirect comparison of antidepressants showed that Trintellix may be more effective than Prozac. Prozac is available as a brand-name drug and in a generic form called fluoxetine. Generic Prozac is much less expensive than Trintellix. But Trintellix is usually less expensive than Prozac.